1586: Identifying the Genetic Cause of Sebaceous Adenitis

Grant Status: Closed

Grant Amount: $71,983.95
Dr. Sandra N. Koch, DVM, University of Minnesota
February 1, 2012 - January 31, 2014
Sponsor(s): Havanese Club of America
Breed(s): Havanese
Research Program Area: Dermatology and Allergic Disease

Project Summary

Sebaceous adenitis (SA) is an inflammatory skin disease of unknown cause. It has been reported in several breeds of dogs, including Havanese dogs. The clustering of SA in Havanese dogs indicates that there is very likely a significant genetic component and possibly a related gene of major effect. We performed genetic analysis from DNA from a total of 104 purebred Havanese dogs. Forty-three dogs were affected with SA and 61 were unaffected. This Genome wide association study using the latest canine SNP chips (DNA marker tools) has identified three total  regions on two different chromosomes associated with the disease in Havanese dogs, and candidate genes are currently being sequenced in these areas to hopefully find the genetic contributors to SA in Havanese dogs. The ultimate goal is to develop DNA-based tests for susceptibility to SA that would be used for diagnostic confirmation and for breeding decisions to help reduce its incidence and potentially develop more specific therapies to better control this disorder.

Publication(s)

None at this time.

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