00800-A: Cataloging the Gene Expression Profiles of Canine Normal Tissues: The Dog in the Post Genomic Era

Grant Status: Closed

Grant Amount: $11,750
Dr. Melissa Paoloni, DVM PhD, National Cancer Institute
June 1, 2006 - March 31, 2007
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

The genes expressed in organs dictate their functionality. Previously gene expression within tissues could only be interrogated on an individual gene-by-gene basis. However, a new technology known as microarrays now allows scientists to look more globally at the large-scale gene expression within tissues. In order to better understand the etiology of various diseases the genes over-expressed in these conditions can be telling. To better understand which expressed genes are players in a diseased state, comparison to the expression within the same normal organ is key. This study aims to establish the gene expression of key normal organs in veterinary research. A free, web-based database would then be created to post these expression profiles for other scientists so the same control experiments would not need to be repeated sparing both time and resources. Database construction will allow the iterative addition of tissues of interest over time. Future efforts may involve the expansion of this database to include normal tissues from specific breeds of interest to the veterinary research community.

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