2003: Anchoring the Canine Map Through BAC Mapping

Grant Status: Closed

Grant Amount: $180,000
Dr. Elaine A Ostrander, PhD, Fred Hutchinson Cancer Research Center
July 5, 2000 - September 30, 2003
Sponsor(s): Geraldine Rockefeller Dodge Foundation, Newfoundland Club of America Charitable Trust
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

Genome maps are essential in identifying genes that cause inherited disease. They consist of a series of markers, positioned along each chromosome, which act as reference points for navigating different regions of the genome. Currently, the canine map is composed of about several hundred such markers, which provide "addresses" for over 90 percent of the genome. This early version of the map has proven useful for identifying the general location of several disease genes. But a much more highly refined map is necessary if we are to actually clone disease genes of interest (not just identify their location) and, subsequently, develop highly reproducible genetic tests. This proposal aims to characterize several hundred random clones, each containing a small portion of the canine genome, and then mapping them on the existing map relative to the markers and genes already in place. These clones, called BACs, will serve as "entry points" along the canine genome. Once a region of the genome is identified where a disease gene lies, the BAC clones will serve as starting points for investigators to genetically "walk" up and down the region and eventually clone the gene of interest. The work done as a result of this proposal is not breed specific, rather it will benefit all breeds of dogs equally.

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