2012: Development of PCR Multiplexed Canine Marker Panels for the Purposes of Genome Screening and Linkage Analysis

Grant Status: Closed

Grant Amount: $130,000
Dr. Marcia Eggleston, PhD, University of California, Davis
July 19, 2000 - September 30, 2002
Sponsor(s): Bernese Mountain Dog Club of America, Bull Terrier Club of America, Bull Terrier Welfare Foundation, Geraldine Rockefeller Dodge Foundation, Golden Retriever Foundation, Miniature Bull Terrier Club of America, Newfoundland Club of America Charitable Trust, Norwegian Elkhound Association of America, Inc., Pug Dog Club of America, Inc.
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

A number of tests have been developed to screen for affected or carrier animals with genetic diseases. The development of many of these tests was possible due to the availability of information regarding similar disorders in humans. The majority of disorders affecting purebred dogs have no known counterpart in humans and therefore no candidate gene. However, an indirect test that screens for a strong association of a microsatellite DNA marker with a disease phenotype can be incorporated in a simple diagnostic test for carriers of the trait. The ultimate goal of the research is to design marker panels containing a minimum of 300 microsatellite markers covering all the linkage groups or chromosomes of the canine genome. The Veterinary Genetics Laboratory has completed panels containing 100 markers with known map locations. This project will incorporate at least 200 additional markers that will then represent the entire canine genome and allow effective screening for linkage of markers to disease gene(s).

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