2248: Generation of Canine EST Resources

Grant Status: Closed

Grant Amount: $100,000
Dr. Richard W. McCombie, PhD, Cold Spring Harbor Laboratory
July 20, 2001 - June 30, 2004
Sponsor(s): Geraldine Rockefeller Dodge Foundation
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

The identification of all of the genes, or major elements of heredity, within an organism is revolutionizing biomedical research. This holistic approach referred to as genomics will enable us to understand and eventually solve diseases with complex genetic factors underlying them. While genomic analysis of the dog is at an early stage, the impending completion of the mouse and human genome sequences will allow rapid acceleration of canine genomics. We are proposing to contribute to this process by building resources for gene identification in the dog. This will include constructing libraries of genes from the dog and determining the DNA sequence of a large number of their component genes. These can then be compared to their counterparts from human and mouse.

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