0001808B: An Integrated Linkage and Radiation Hybrid Map of the Dog: A Collaborative Project

Grant Status: Closed

Grant Amount: $150,000
Dr. Francis Galibert, PhD, CNRS - University of Rennes
November 24, 1999 - November 23, 2001
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

Genome maps or organisms are essential for locating and identifying genes that cause inherited disease. They consist of a series of markers, positioned along each chromosome, which act as reference points or address labels for different regions of the genome. Currently, the canine map is composed of about 400 such markers, which, in principal, provides "addresses" for about 75 percent of the genome. This early version of the map has proven useful for identifying the general location of disease genes in several breeds of dog. But a much more highly refined map is necessary if we are to have the ability to actually identify disease genes (not just their location) and to develop highly reproducible genetic tests for canine diseases. In addition, the current version of the map allows us to navigate around the genome only in relatively outbred pedigrees of dog. Many disease genes of interest are found in pedigrees or breeds where a limited gene pool has forced significant levels of inbreeding. A much higher resolution map with many additional markers is necessary to map disease genes within inbred families. This proposal aims to identify numerous additional markers and place them on the canine genome map. In addition, it aims to map many more genes on the map. Finally, it will link the evolving canine map to the more well developed maps of the human and mouse genomes. The resulting map will be useful for the identification of disease genes in all breeds of dog, and should allow canine geneticists to increase the rate at which they identify genes responsible for inherited diseases in the dog.

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