1268: A Genetic Map of the Canine Genome

Grant Status: Closed

Grant Amount: $136,609
Elaine A Ostrander, PhD; Fred Hutchinson Cancer Research Center
June 10, 1996 - June 9, 1999

Sponsor(s): American Sealyham Terrier Club

Breed(s): -All Dogs
Research Program Area: General Canine Health
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Project Summary

This project contributed to the completion of the map of the canine genome. Researchers developed more than 400 microsatellite markers for placement on the map. By the end of this project, a third-generation linkage map was created, spanning 95 percent of the canine genome and containing 335 densely placed markers. The project exceeded the Foundation's goal of developing a dog genome map of 250 markers within three years. The researchers also developed screening sets of markers that have the highest likelihood of being informative, called minimal mapping set 1. At the end of the project, the linkage map had already been used to find several disease genes, including that for canine progressive rod-cone disease (prcd), a form of progressive retinal atrophy, in Labrador Retrievers, Portuguese Water Dogs, Poodles, English and American Cocker Spaniels, and potentially more breeds. Research continues to map more markers. This growing database of knowledge provides the basis for other researchers to find genes that cause diseases in dogs.

Publication(s)

Richman, M., Mellersh, C. S., André, C., Galibert, F., & Ostrander, E. A. (2001). Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome. Journal of Biochemical and Biophysical Methods, 47(1–2), 137–149. https://doi.org/10.1016/S0165-022X(00)00160-3
 
Sidjanin, D. J., Zangerl, B., Johnson, J. L., Xue, F., Mellersh, C., Ostrander, E. A., … Aguirre, G. D. (2002). Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9. Animal Genetics, 33(2), 161–162. https://doi.org/10.1046/j.1365-2052.2002.0831d.x

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