1268: A Genetic Map of the Canine Genome

Grant Status: Closed

Grant Amount: $136,609.22
Dr. Elaine A Ostrander, PhD, Fred Hutchinson Cancer Research Center
June 10, 1996 - June 9, 1999
Sponsor(s): American Sealyham Terrier Club
Breed(s): -All Dogs
Research Program Area: Prevention

Project Summary

This project contributed to the completion of the map of the canine genome. Researchers developed more than 400 microsatellite markers for placement on the map. By the end of this project, a third-generation linkage map was created, spanning 95 percent of the canine genome and containing 335 densely placed markers. The project exceeded the Foundation's goal of developing a dog genome map of 250 markers within three years. The researchers also developed screening sets of markers that have the highest likelihood of being informative, called minimal mapping set 1. At the end of the project, the linkage map had already been used to find several disease genes, including that for canine progressive rod-cone disease (prcd), a form of progressive retinal atrophy, in Labrador Retrievers, Portuguese Water Dogs, Poodles, English and American Cocker Spaniels, and potentially more breeds. Research continues to map more markers. This growing database of knowledge provides the basis for other researchers to find genes that cause diseases in dogs.

Publication(s)

- Francisco LV, Langston AA, Mellersh CS, Neal CL, Ostrander EA. A class of highly polymorphic tetranucleotide repeats for canine genetic mapping. Mamm Genome. 1996 May;7(5):359-62. - Szabo CI, Wagner LA, Francisco LV, Roach JC, Argonza R, King MC, Os

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