03259-A: Screening for Genetic Variants Using Whole Exome Sequencing in Dogs with Protein-losing Enteropathy
Grant Status: Open
One Health: Yes
Abstract
Canine protein-losing enteropathy (PLE) is a life-threatening syndrome characterized by loss of protein in the feces due to disease of the small intestine. The exact mechanisms that lead to protein loss are not well understood and approximately 50% of affected dogs die from their disease.
Recently, genetic testing has led to the discovery of new diseases causing PLE in humans. In some cases, these discoveries have led to the development of a novel, successful treatment for a previously fatal condition. Similar genetic testing has not been reported for a group of varied breeds of dogs with PLE. The researchers will perform an exploratory project utilizing specific genetic testing on archived samples from a diverse group of meticulously characterized dogs with PLE. They expect this project to spur future investigations into the potential genetic basis and mechanisms of disease in cases of canine PLE. The long-term goal is to develop genetic screening tests for breeding animals to eliminate the risk mutations from the population. They also aim to discover novel therapies for dogs affected by PLE to improve responses to therapies and long-term survival.
Publication(s)
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
