03040: Identification of Novel Epilepsy Genes in Dogs

Grant Status: Closed

Grant Amount: $30,000
Hannes T. Lohi, PhD; The Folkhälsan Institute of Genetics
July 1, 2022 - December 31, 2023

Sponsor(s): Australian Shepherd Health & Genetics Institute, Boston Terrier Club of America, Duffee Standard Schnauzer Epilepsy Research Fund, Vizsla Club of America Welfare Foundation

Breed(s): -All Dogs
Research Program Area: Epilepsy Initiative
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Epilepsy is the most common neurological problem in dogs and affects most breeds. Genetics plays a significant role in seizure susceptibility, but gene discoveries have been rare due to clinical and genetic heterogeneity. Investigators have recently completed a genome-wide association study in ~600 Labrador Retrievers (LRs) and successfully mapped two loci with genome-wide significance in dogs affected by focal epilepsy or paroxysmal dyskinesia. In this study, investigators will recruit new epileptic LRs with focal seizures or paroxysmal dyskinesia to independently replicate the identified loci, and then perform in-depth analysis of the regions to identify candidate causal variants. If successful, the study will validate new epilepsy loci and reveal new epilepsy genes to improve diagnostics, understanding, and care of the disease in LRs and possibly other breeds.


None at this time.

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