03028-A: Characterizing Immunohistopathology and Serum Immunoglobulin G in Immune-Mediated Chronic Hepatitis Dogs

Grant Status: Open

Grant Amount: $14,999
Sarah Shropshire, DVM, PhD; Colorado State University
February 1, 2022 - January 31, 2023

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Hepatic Disease
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Abstract

Immune-mediated chronic hepatitis (ICH) is a highly prevalent liver disorder in dogs that can progress to liver failure if undiagnosed or untreated. An autoimmune cause is suspected because the disease responds to immunosuppressive medications such as cyclosporine. However, the immune features and pathogenesis of ICH have not been fully characterized and the diagnostic criteria have not been established yet. Thus, the diagnosis of ICH continues to be a challenge. Furthermore, the effects of cyclosporine treatment on the immune system in ICH dogs need to be articulated. This study aims to characterize the unique immune features of ICH and how they respond to cyclosporine treatment. These features will serve as biomarkers of disease diagnosis, treatment response to cyclosporine, and prognosis.

Publication(s)

None at this time.

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