03028-A: Characterizing Immunohistopathology and Serum Immunoglobulin G in Immune-Mediated Chronic Hepatitis Dogs
Grant Status: Open
Abstract
Immune-mediated chronic hepatitis (ICH) is a highly prevalent liver disorder in dogs that can progress to liver failure if undiagnosed or untreated. An autoimmune cause is suspected because the disease responds to immunosuppressive medications such as cyclosporine. However, the immune features and pathogenesis of ICH have not been fully characterized and the diagnostic criteria have not been established yet. Thus, the diagnosis of ICH continues to be a challenge. Furthermore, the effects of cyclosporine treatment on the immune system in ICH dogs need to be articulated. This study aims to characterize the unique immune features of ICH and how they respond to cyclosporine treatment. These features will serve as biomarkers of disease diagnosis, treatment response to cyclosporine, and prognosis.
Publication(s)
None at this time.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
