02998: Whole-Exome and Transcriptome Sequencing of Canine Small Cell B Cell Lymphoma and Comparative Analysis to Diffuse Large B Cell Lymphoma

Grant Status: Open

Grant Amount: $58,136
Anne Avery, DVM, PhD; Colorado State University
March 1, 2022 - February 29, 2024

Sponsor(s): Golden Retriever FoundationĀ®

Breed(s): -All Dogs
Research Program Area: Oncology - Lymphoma
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One Health: Yes

Abstract

Lymphoma is a common canine tumor. Diffuse large B cell lymphoma is the most common type of B cell lymphoma in dogs, but there are less common B cell lymphoma types that have aggressive behavior and little is known about the mechanisms driving these tumors. The goal of this study is to genetically characterize these less common forms and compare these findings to diffuse large B cell lymphoma. This will inform whether targeted therapies for diffuse large B cell lymphoma, including ones developed for human patients, are useful for other B cell lymphoma types. Investigators will also study patient outcome in these cases to identify prognostic factors and work to develop tests that more accurately diagnose clinically important subtypes of B cell lymphoma. This work will improve our understanding of canine B cell lymphoma to advance diagnosis and prognosis and develop better therapies to improve outcomes.

Publication(s)

None at this time.

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