02987: It’s All In The Genes: The Mutational Landscape of Acute Myeloid Leukemia in Dogs

Grant Status: Open

Grant Amount: $109,183
Tracy Stokol, BVSc, PhD; Cornell University
January 1, 2022 - December 31, 2023

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Blood Disorders, Oncology
Donate to Support this Research Program Area

One Health: Yes

Abstract

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because there are not many drugs that can treat leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease seen in dogs, and now there are new treatment options, longer patient survival, and the disease can be more accurately divided into subtypes to better inform treatment and prognosis. In fact, treatments are often tailored to the specific subtype of leukemia in the patient, which is known as precision medicine. All of these improvements in the diagnosis, treatment and prognostication of acute myeloid leukemia in humans have been made possible by genetic testing and identification of specific genetic defects or mutations that are responsible for the tumor. However, unlike humans, very little is known about the genetic mutations that underlie acute myeloid leukemia in dogs. In this multi-institutional study involving blood cancer specialists in veterinary and human medicine, investigators will perform in-depth genetic analysis of 50 dogs with acute myeloid leukemia by sequencing the genes within the tumor. Relevant genetic mutations will be identified by comparing gene sequences of the cancer cells to those of normal tissue. From this genetic analysis, investigators hope to identify mutations in acute myeloid leukemia in dogs that would be responsive to newer treatments or that could be targeted for development of new drugs. In turn, they could more accurately classify affected dogs into subtypes, which would help veterinarians better inform owners of prognosis and treat the dogs with more appropriate therapy, thereby prolonging their life, just as accomplished in humans.

Learn how you can participate in this research!

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.