02950-A: Late-onset Hereditary Cataract in the Boston Terrier: A Whole Genome Sequencing Approach

Grant Status: Closed

Grant Amount: $8,541
Kathryn T. Graves, PhD; University of Kentucky Research Foundation
August 1, 2021 - July 31, 2022


Breed(s): Boston Terrier
Research Program Area: Ophthalmology
Donate to Support this Research Program Area


Identifying mutations for heritable cataracts in dogs has proved to be frustrating; with only one gene (HSF4) being discovered to date that harbors mutations associated with cataract in four breeds of dogs, including the Boston Terrier. At least two types of cataract are found in the Boston Terrier, an early-onset hereditary cataract (EHC) caused by the HSF4 mutation, and a late-onset hereditary cataract (LHC) found in dogs over four years of age. Factors confounding the discovery of additional mutations include inconsistencies in tracking cataract progression, such as age of onset and rate of progression, in addition to the location of the cataract within the lens. Advances in genetic technologies such as whole genome sequencing provide a potential avenue to discovery of the causative mutations for hereditary cataracts in dogs, a vexing problem for breeders and owners. This study aims to take advantage of the significant decrease in the cost of whole genome sequencing of individual animals, coupled with access to a family of Boston Terriers where cataract occurrence and progression has been tracked across generations.


None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813


© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.