02936: Validating Genetic Variants Underlying Canine Idiopathic Epilepsy and Exploring Their Functional Roles in the Belgian Sheepdog and Tervuren

Grant Status: Open

Grant Amount: $108,000
Anita M. Oberbauer, PhD; University of California, Davis
May 1, 2021 - October 31, 2022

Sponsor(s):

Breed(s): Belgian Tervuren, Belgian Sheepdog
Research Program Area: Epilepsy Initiative
Donate to Support this Research Program Area

Abstract

Canine epilepsy is a debilitating condition and, unfortunately, an all too common neurological disease with impact on a dog’s health and well-being, and a significant emotional toll on owners. Epilepsy is known to be inherited, and therefore characterizing the causal genetic alterations is important to assist in breeding decisions as well as reveal pathways that could be useful targets for therapeutic intervention to mitigate the seizures themselves. Although fairly widespread among all dogs, the prevalence of idiopathic epilepsy (IE) is considered elevated and a recognized health concern in the Belgian Sheepdog (BS) and Belgian Tervuren (BT) relative to other dog breeds, making them good candidate breeds for genetic studies on IE. In addition, it was through research on these breeds that an IE risk variant in the ADAM23 gene was initially discovered and then found to be a common risk variant across many breeds although the ADAM23 variant fails to completely explain disease expression in any of the breeds indicating the need for further exploration of causal variants contributing to disease expression in dogs. Investigators recently identified a novel genomic region on canine chromosome 14 (CFA14) associated with increased risk for IE in BS and BT dogs. When combined with the ADAM23 region, the risk for IE was further increased. The present research, while focusing on the BS and BT breeds, aims to validate the involvement of the risk region on CFA14 in these and other breeds, investigate the functional changes associated with the variants while discovering additional genetic variants underlying IE susceptibility, and provide insight into the regulatory components of this disorder pertinent to many breeds.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software