02907: Ultrasound-guided Histotripsy Ablation of Canine Brain Tumors through an Acoustically Transparent Cranial Window

Grant Status: Open

Grant Amount: $106,783
John Rossmeisl, DVM, MS; Virginia-Maryland Regional College of Veterinary Medicine
June 1, 2021 - May 31, 2024


Breed(s): -All Dogs
Research Program Area: Oncology
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One Health: Yes


Meningiomas and gliomas account for 85% of canine primary brain tumors (PBT). These neoplasms are common in several dog breeds and a significant cause of morbidity and mortality. Surgery remains a mainstay of treatment for canine PBT, with the goal of achieving gross total surgical resection. However, significant proportions of canine PBT are considered inoperable due to their location in the brain, local recurrence after surgery remains a major mode of treatment failure, and conventional surgical techniques are invasive and often associated with adverse neurological events.  As such, the clinical evaluation of the biologic effects of novel approaches for managing non-resectable or recurrent PBT is warranted to improve quality and quantity of life in dogs.  In this study, the safety and feasibility of using ultrasound-guided histotripsy, a non-invasive and non-thermal acoustic method of tissue ablation, to treat canine primary brain tumors (PBT) will be investigated.  This proof-of-concept of study will provide foundational data necessary to further evolve histotripsy technology towards completely non-invasive transcranial applications.  Results have the potential to cause a clinical practice paradigm shift that will allow precision image-guided, non-invasive treatment of PBT using ultrasonographic equipment and techniques that are currently in use in the majority of small animal veterinary practices.


None at this time.

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