02864-A: Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells

Grant Status: Open

Grant Amount: $11,718
Michelle Kutzler, DVM, PhD; Oregon State University
February 1, 2021 - January 31, 2022

Sponsor(s): American Bouvier des Flandres Club - Bouvier Health Foundation, Golden Retriever FoundationĀ®, Jeffrey Pepper

Breed(s): Golden Retriever, Labrador Retriever, German Shepherd Dog, -All Dogs
Research Program Area: Oncology - Hemangiosarcoma
Donate to Support this Research Program Area

Abstract

Hemangiosarcoma is an aggressive, silent cancer that sometimes snares its victims without any sign of illness. In the U.S., hemangiosarcoma is believed to be responsible for the deaths of tens of thousands of dogs each year. German Shepherd Dogs, Golden Retrievers, and Labrador Retrievers are most commonly affected but this cancer affects all dogs. While there is no cure, early surgical intervention and chemotherapy treatment may prolong the lives of dogs afflicted with hemangiosarcoma. Additional treatment options are needed to increase life expectancy and possibly even prevent the development of this deadly disease. Several studies have shown that spayed female dogs have a two- to ten-fold increase for developing hemangiosarcoma compared to intact female dogs. This may be due to overproduction of luteinizing hormone (LH) following spay or neuter. Investigators have previously demonstrated that hemangiosarcoma tissues collected from dogs have binding sites for LH. The proposed research will determine if LH binding to these sites increases cancer cell growth. The results of this research may allow for a better understanding of the relationship between spaying or neutering and the development of hemangiosarcoma. In addition, future development of a method to reduce LH secretion in spayed or neutered dogs may lower the risk for some breeds to develop hemangiosarcoma.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

Ā© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software