02829: Investigating the Potential of Phage Therapy to Tackle Staphylococcus pseudintermedius Infections in Dogs

Grant Status: Open

Grant Amount: $99,830
Gavin Paterson, PhD; R(D)SVS and Roslin Institute, University of Edinburgh
January 1, 2021 - February 28, 2022

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Dermatology and Allergic Disease
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One Health: Yes

Abstract

The spread of antimicrobial resistance is a major threat to modern medicine, for both humans and animals. In the case of dogs, Staphylococcus pseudintermedius is an important cause of infections, especially pyoderma. Antimicrobial resistance in S. pseudintermedius is making infections more difficult to treat which is affecting dog welfare and might pose a threat to humans too. There is a need to explore alternative treatments to antibiotics with one approach being to use phage therapy. This therapy uses naturally-occurring viruses, called bacteriophages (phages) which infect and kill bacteria to treat bacterial infections. Phage therapy has a long history of safe and effective use in humans and has the advantages that it can target drug resistance bacteria with few side effects. This project has a team of veterinarians and scientists working together to isolate and characterize phages that kill S. pseudintermedius which may contribute to the development of new, exciting treatments to benefit dog health and wellbeing.

Publication(s)

None at this time.

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