02807-MOU: Characterization of Renal Disease in Greyhound Dogs

Grant Status: Open

Grant Amount: $36,181
Rachel E Cianciolo, VMD, PhD; Ohio State University
June 1, 2020 - May 31, 2022

Sponsor(s): Greyhound Club of America

Breed(s): Greyhound
Research Program Area: Kidney & Urological Disease
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Abstract

Kidney disease is common in dogs, and some dog breeds seem to be more predisposed to development of kidney disease than other breeds. Greyhounds appear to be predisposed to proteinuric renal diseases; however, a complete characterization of the most common types of kidney diseases in this breed has not been performed to date, and potential genetic causes of kidney diseases in Greyhounds remain unknown. Preliminary data based on evaluation of cases through the International Veterinary Renal Pathology Service and Ohio State University has revealed that kidney disease in Greyhounds is likely from a variety of causes; including primary glomerular diseases and glomerular damage secondary to hypertension. For this study, samples will be prospectively collected to identify Greyhounds with kidney disease, determine which are proteinuric, localize the origin of proteinuria (glomerular versus tubulointerstitial), and identify dogs for further evaluations and monitoring. Prospective examination of kidney samples from pedigreed Greyhounds using advanced techniques (transmission electron microscopy and immunofluorescence) will ensure accurate diagnosis of renal injury. Detailed review of archived samples from Greyhounds will allow identification of common renal lesions. DNA will also be banked for future genomic studies if a hereditary component to kidney disease is detected in the breed.

Funding for the research is provided through the collaborative efforts and generosity of the Greyhound Club of America. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress.

Publication(s)

None at this time.

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