02800: Defining the Effect of Genotype, Breed and Age on the Risk of Developing Canine Degenerative Myelopathy and Investigating the Molecular Mechanisms Underlying That Risk

Grant Status: Open

Grant Amount: $108,000
Gary S. Johnson, DVM, PhD and Joan Coates, DVM, MS; University of Missouri
April 1, 2020 - March 31, 2021

Sponsor(s): American Bloodhound Club, Collie Health Foundation, SCWTCA Endowment, Inc., Soft Coated Wheaten Terrier Club of America, Inc., Soft Coated Wheaten Terrier Genetic Research Fund

Breed(s): -All Dogs
Research Program Area: Neurology
Donate to Support this Research Program Area

Abstract

Canine degenerative myelopathy (DM) is a progressive and inevitably fatal neurological disease affecting members of different dog breeds and mixes. It is an inherited disease with an age-related penetrance. The risk of developing the disease when dogs are homozygous for the causal SOD1 variant allele is currently unknown but of great concern to dog breeders and owners. The proposed research will further define the risk for developing DM in genetically at-risk dogs with a health survey distributed to dog owners whose dogs have been tested for the risk factor allele. This work will also examine the molecular mechanisms responsible for disease onset and spread by comparing single-nucleus RNA expression patterns in specific cell types in dorsal root ganglia from normal dogs and from affected dogs at various stages of the disease. 

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software