02782: Genetic Contribution to Early-onset Osteosarcoma

Grant Status: Open

Grant Amount: $161,718
Susannah Sample, DVM, MS, PhD; University of Wisconsin, Madison
March 1, 2020 - February 29, 2024

Sponsor(s): Irish Wolfhound Foundation, Irish Wolfhound Club of America, Inc.

Breed(s): Irish Wolfhound
Research Program Area: Oncology - Osteosarcoma
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Abstract

Osteosarcoma is a devastating disease that affects many dog breeds. Although osteosarcoma is typically a disease of older dogs, in some breeds, such as the Irish Wolfhound, dogs can be affected at a young age. This study will investigate the genetic basis of early-onset osteosarcoma in the Irish Wolfhound breed. Osteosarcoma is responsible for ~20% of deaths in the Irish Wolfhound breed, with many dogs being diagnosed before 5 years of age. Consequently, there is a critical need to advance understanding of the genetic basis of early-onset osteosarcoma in the Irish Wolfhound. State-of-the-art DNA sequencing will provide insight into an osteosarcoma-associated genetic variant that strongly influences disease risk in young Irish Wolfhounds. This discovery, with subsequent development of a genetic screening test, will contribute to selective breeding decisions to decrease osteosarcoma prevalence in the Irish Wolfhound breed. Findings can then be applied to other osteosarcoma-predisposed breeds. The genomic research approach will also have substantial impact in method development for other genetic studies of rare diseases in dogs or diseases in rare breeds.

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