02773: Histotripsy for Treatment of Canine Appendicular Osteosarcoma
Grant Status: Closed
One Health: Yes
Abstract
Osteosarcoma (OS) is the most common bone cancer in dogs. Large and giant breeds such as Irish Wolfhound, Great Dane, Greyhound, Scottish Deerhound, Rottweiler, Boxer, Saint Bernard, and Irish Setter are most affected. OS is treated with a combination of surgical removal of the primary tumor and chemotherapy for metastatic disease. Surgical removal of the tumor usually involves limb amputation or limb salvage surgery, which can have high complication rates, and not all dogs are suitable for limb amputation. Even after surgical tumor removal and chemotherapy, the cancer often metastasizes and dogs usually die of metastatic disease within an average of 12 months after diagnosis. Survival times have not greatly improved over the last 30 years. Histotripsy is a precision non-thermal focused ultrasound method that mechanically breaks down tissues, can potentially induce immune activation towards an anti-OS immune response, and is an emerging modality for treating multiple cancers including liver and brain cancer. A non-surgical option for treatment of the primary tumor in OS will help patients preserve their limb and avoid complications of surgical limb-salvage. A therapy that stimulates an anti-tumor immune response may increase OS survival. This study aims to evaluate the efficacy of histotripsy to treat dogs with OS, to ultimately advance the development of histotripsy as a limb salvage treatment option for primary OS and an immunotherapy treatment against metastatic disease for OS.
Publication(s)
Hay AN, Vickers ER, Patwardhan M, et al. Investigating cell death responses associated with histotripsy ablation of canine osteosarcoma. International Journal of Hyperthermia. 2023;40(1):2279027. https://doi:10.1080/02656736.2023.2279027
Alayna N. Hay, Lauren Ruger, Andy Hsueh, Elliana Vickers, Shawna Klahn, Eli Vlaisavljevich & Joanne Tuohy (2023) A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments, International Journal of Hyperthermia, 40:1, 2274802, https://DOI: 10.1080/02656736.2023.2274802
Alayna N. Hay, Elliana R. Vickers, Manali Patwardhan, Jessica Gannon, Lauren Ruger, Irving C. Allen, Eli Vlaisavljevich & Joanne Tuohy (2023) Investigating cell death responses associated with histotripsy ablation of canine osteosarcoma, International Journal of Hyperthermia, 40:1, https://DOI: 10.1080/02656736.2023.2279027
Alayna N. Hay, Lauren Ruger, Andy Hsueh, Elliana Vickers, Shawna Klahn, Eli Vlaisavljevich & Joanne Tuohy (2023) A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments, International Journal of Hyperthermia, 40:1, 2274802, https://DOI: 10.1080/02656736.2023.227480
Latifi M, Hay A, Carroll J, Dervisis N, Arnold L, Coutermarsh-Ott SL, Kierski KR, Klahn S, Allen IC, Vlaisavljevich E, Tuohy J. Focused Ultrasound Tumor Ablation in Small Animal Oncology. Veterinary and Comparative Oncology 2021Sep;19(3):411-419
Arnold A, Hendricks-Wenger A, Coutermarsh-Ott S, Gannon J, Hay A, Dervisis N, Klahn S, Allen IC, Tuohy J, Vlaisavljevich E. Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors. Ultrasound in Medicine and Biology 2021 Dec;47(12):3435-3446. PMID: 34462159
Latifi M, Hay A, Carroll J, Dervisis N, Arnold L, Coutermarsh-Ott SL, Kierski KR, Klahn S, Allen IC, Vlaisavljevich E, Tuohy J. Focused Ultrasound Tumor Ablation in Small Animal Oncology. Veterinary and Comparative Oncology 2021Sep;19(3):411-419. PMID: 34057278
Hendricks-Wenger A, Arnold L, Gannon J, Simon A, Signh N, Sheppard H, Nagai-Singer M, Khan I, Lee K, Clark-Deener S, Bryon C, Larson M, Rossmeisl J, Coutermarsh-Ott S, Dervisis N, Klahn S, Tuohy J, Allen IC, Vlaisavljevich E. Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review. Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2022 Jan;69(1):5-26. PMID: 34478363
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