02739-A: The Role of the Putative Tumor Suppressor Gene SETD2 in Canine Diffuse Large B-cell Lymphoma

Grant Status: Open

Grant Amount: $14,996
Bonnie Harrington, DVM, PhD; Michigan State University
February 1, 2020 - January 31, 2022

Sponsor(s): Australian Shepherd Health and Genetics Institute, Inc., Collie Health Foundation, Irish Setter Club of America Foundation, Inc.

Breed(s): -All Dogs
Research Program Area: Oncology - Lymphoma
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Abstract

Lymphoma is a common, deadly cancer affecting both humans and dogs. Effective therapies without side effects are lacking. This study will investigate the role of a gene called SETD2 in the development of canine lymphoma. SETD2 is often disrupted in human cancers, including lymphoma, and preliminary data suggest a similar gene disruption in canine lymphoma. The work set forth will confirm alteration of this gene in dogs and evaluate whether and how it is related to clinical factors, including severity of disease, resistance to treatment, and dog breed. Overall, these studies will establish the significance of SETD2 dysfunction in canine lymphoma, laying the groundwork for future investigations to understand how this gene contributes to cancer development and how to more effectively treat canine lymphoma.

Publication(s)

None at this time.

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