02723: Scientific and Clinical Assessment of Fecal Microbiota Transplant in Obese Dogs: SLIM Study
Grant Status: Open
Obesity is a growing epidemic in companion animals. Obesity results from a prolonged positive energy balance leading to excessive fat accumulation, which promotes dysregulation of metabolic, hormonal, and inflammatory responses. Ultimately these changes lead to physical impairment, comorbidities, and reduced quality of life. Evidence is mounting that the intestinal microbiota (collection of microorganisms that live in the intestines) contributes to obesity, and rational manipulation of this ecosystem may confer a health benefit. This study will provide a comprehensive scientific and clinical assessment of the efficacy of fecal microbiota transplantation (FMT) as an adjunctive therapy for canine obesity management. The investigators hypothesize that FMT (the transfer of feces from a healthy, lean donor dog into an obese dog) will amplify weight loss in obese dogs compared to the use of standard dietary obesity management. A randomized, placebo controlled clinical trial in client-owned obese dogs consisting of three groups: diet alone, diet + FMT, diet + placebo will provide data on weight loss and characterize the intestinal microbiota and metabolic function. Success of this study will benefit obese dogs by providing a microbial intervention to augment current strategies for canine obesity management aimed at promoting weight loss, normalizing metabolic status, and improving quality of life.
Moore, Rustin M., Vanessa Hale, Jenessa Winston, and Toni Hare. “Harnessing the Microbiome to Improve the Health and Well-Being of Animals and People.” American Journal of Veterinary Research 1, no. aop (August 5, 2023): 1–1. https://doi.org/10.2460/ajvr.23.07.0156.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.