02703: Resolving the Major Dyslipidemia Phenotypes and Genetic Risk Factors for Familial Hyperlipidemia in Miniature Schnauzers

Grant Status: Open

Grant Amount: $98,404
Eva Furrow, VMD, PhD; University of Minnesota
April 1, 2020 - March 31, 2022

Sponsor(s):

Breed(s): Miniature Schnauzer
Research Program Area: Blood Disorders
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Abstract

Familial hyperlipidemia reportedly afflicts more than 75% of Miniature Schnauzers by 10 years of age. This condition is defined as too much circulating lipid (fat) in the bloodstream. Familial hyperlipidemia predisposes dogs to other serious diseases which impact their health and wellbeing. Management of familial hyperlipidemia is hampered by gaps in the understanding of its metabolic and genetic origin. Investigators aim to uncover the metabolic and genetic causes of hyperlipidemia in Miniature Schnauzers. Preliminary data revealed evidence for more than one type of familial hyperlipidemia within the breed. In this study, metabolomics/lipidomics will be used to identify and quantify over 2000 substances in the blood related to metabolism of lipids and other nutrients, classifying them into types of familial hyperlipidemia. Whole genome sequencing will be used to generate a list of hyperlipidemia mutations that may contribute to one or more types of familial hyperlipidemia. Identifying the different types of familial hyperlipidemia and their respective genetic risk factors in Miniature Schnauzers will lead to improved understanding and treatment of the condition, with individualized therapies and genetic tests used to identify at risk dogs that will benefit from early intervention and monitoring.

Publication(s)

None at this time.

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