02703: Resolving the Major Dyslipidemia Phenotypes and Genetic Risk Factors for Familial Hyperlipidemia in Miniature Schnauzers
Grant Status: Open
Abstract
Familial hyperlipidemia reportedly afflicts more than 75% of Miniature Schnauzers by 10 years of age. This condition is defined as too much circulating lipid (fat) in the bloodstream. Familial hyperlipidemia predisposes dogs to other serious diseases which impact their health and wellbeing. Management of familial hyperlipidemia is hampered by gaps in the understanding of its metabolic and genetic origin. Investigators aim to uncover the metabolic and genetic causes of hyperlipidemia in Miniature Schnauzers. Preliminary data revealed evidence for more than one type of familial hyperlipidemia within the breed. In this study, metabolomics/lipidomics will be used to identify and quantify over 2000 substances in the blood related to metabolism of lipids and other nutrients, classifying them into types of familial hyperlipidemia. Whole genome sequencing will be used to generate a list of hyperlipidemia mutations that may contribute to one or more types of familial hyperlipidemia. Identifying the different types of familial hyperlipidemia and their respective genetic risk factors in Miniature Schnauzers will lead to improved understanding and treatment of the condition, with individualized therapies and genetic tests used to identify at risk dogs that will benefit from early intervention and monitoring.
Publication(s)
Tate, N.M.; Underwood, M.; Thomas-Hollands, A.; Minor, K.M.; Cullen, J.N.; Friedenberg, S.G.; Mickelson, J.R.; Xenoulis, P.G.; Steiner, J.M.; Furrow, E. Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia. Genes 2024, 15, 193. https://doi.org/10.3390/genes15020193
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