02556-MOU: Identification of the Molecular Genetic Cause for Cystinuria in Irish Terriers

Grant Status: Closed

Grant Amount: $10,000
Gary S. Johnson, DVM, PhD; University of Missouri
December 1, 2018 - May 31, 2020

Sponsor(s): Irish Terrier Club of America

Breed(s): Irish Terrier
Research Program Area: Kidney & Urological Disease
Donate to Support this Research Program Area


The goal of this study is to identify the molecular genetic case for cystinuria in Irish Terriers.  Preliminary data was obtained from DNA samples of Irish Terriers affected with cystinuria.  The investigators generated and analyzed a whole genome sequence (WGS) from an affected Irish Terrier; however, no variants in cystinuria-associated genes were identified.  Using additional dogs and WGS, the investigators will look for rare genetic variants in affected dogs using latest technologies, including an Oxford Nanopore sequencer to effectively detect potentially causal sequence variants.

Funding for the research is provided through the collaborative efforts and generosity of the Irish Terrier Club of America. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress.


None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813


© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.