02366-A: Individualization of Pharmacological Interventions in Diabetic Dogs

Grant Status: Closed

Grant Amount: $14,435
Nicolas Villarino, Med.Vet., DVSc, PhD; Washington State University
May 1, 2017 - April 30, 2019


Breed(s): -All Dogs
Research Program Area: Endocrinology
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Diabetes mellitus is a disease of middle-aged to older dogs which means many affected dogs will develop other diseases such as arthritis, infections, and behavior disorders, all requiring drug therapy. Poor control of glucose levels in diabetic dogs can alter how drugs behave in the body, which can result in drug toxicities. This is an area of intense investigation in diabetic humans, but such effects have not been investigated in canine medicine, and prescribed treatments may result in individual dogs being under- or overdosed. The investigators intend to move from a 'one dose fits all' strategy to an individualized medical approach to ensure each patient receives optimal pharmacological therapy. Completion of this study is the first step toward establishing an in vitro method for evaluating the many drugs used in diabetic dogs. The long-term goal is to develop a free downloadable application for mobile devices (smartphones and tablets) for use by clinicians to make treatment selection, and to avoid drugs that may cause problems in diabetic patients. This research stands to play a substantial role in the clinical management of dogs with diabetes mellitus.


None at this time.

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