02175-A: Development of a Brucellosis Vaccine for Dogs

Grant Status: Closed

Grant Amount: $12,952
Angela M Arenas, DVM, PhD; Texas A&M AgriLife Research
October 1, 2015 - July 31, 2017

Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Health and Rescue Foundation of PBGV Club of America, Labrador Retriever Club, Inc., Siberian Husky Club of America, Inc.

Breed(s): -All Dogs
Research Program Area: Reproductive Conditions
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Abstract

Brucella infections constitute a serious problem for dog breeders, pet owners, and kennels, leading not only to economic costs associated with reproductive loss, but also a public health concern because of the zoonotic potential. The disease, once established, is difficult to control due to the lack of a protective vaccine for canine use. Historically, brucellosis control efforts have demonstrated that the spread of the disease is preventable or significantly reduced in association with vaccination. Unfortunately, efforts to develop a brucellosis vaccine that is safe and effective for dogs have been unsuccessful to date. The goal of this research is to develop a safe and efficacious Brucella canis vaccine using a genetic mutant that has been shown to be safe and efficacious for controlling infection against other Brucella species. The development of a safe and highly protective brucellosis vaccine for dogs will significantly impact canine and human health by limiting the spread of disease.

Publication(s)

Hensel, M. E., Negron, M., & Arenas-Gamboa, A. M. (2018). Brucellosis in Dogs and Public Health Risk. Emerging Infectious Diseases, 24(8), 1401–1406. https://doi.org/10.3201/eid2408.171171

Stranahan, L. W., Chaki, S. P., Garcia-Gonzalez, D. G., Khalaf, O. H., & Arenas-Gamboa, A. M. (2020). Evaluation of the Efficacy of the Brucella canis RM6/66 Δ vjbR Vaccine Candidate for Protection against B. canis Infection in Mice. MSphere, 5(3), e00172-20. https://doi.org/10.1128/mSphere.00172-20.

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