01928-A: A Novel Technique to Reveal the Multiple Genes Associated with Canine Epileptoid Cramping Syndrome

Grant Status: Closed

Grant Amount: $12,960
Gary S. Johnson, DVM, PhD; University of Missouri, Columbia
June 1, 2013 - May 31, 2014

Sponsor(s): Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America

Breed(s): Border Terrier
Research Program Area: Neurology
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Canine Epileptoid Cramping Syndrome (CECS) is a common episodic movement disorder in Border Terriers. The episodes are unpleasant and stressful to both the dogs and their owners. Previous studies based on the premise that most or all of the CECS results from a single genetic cause have failed. Variability in the frequency, duration, and age-at-onset of the CECS episodes support the suspicion that CECS may be a group of diseases rather than one distinct disease. Using well-phenotyped dogs, Dr. Johnson will employ a novel genetic analysis, whole genome alignment, to reveal the genes associated with CECS. The purpose of Dr. Johnson's research is to create a DNA marker test to assist breeders in their efforts to eliminate or mitigate the risk of CECS in future generations of Border Terriers.


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