01828: Mapping of Genetic Risk Factors for Canine Hip Dysplasia

Grant Amount: $79,488

Antti Iivanainen, DVM, PhD; University of Helsinki and the Folkhalsan Institute of Genetics

January 1, 2014 - December 31, 2016

Sponsor(s): American Belgian Tervuren Club, Inc., American Bouvier des Flandres Club - Bouvier Health Foundation, American Brittany Club, Bernese Mountain Dog Club of America, Boykin Spaniel Club and Breeders Association of America, Clumber Spaniel Health Foundation, Collie Health Foundation, National Beagle Club, Norwegian Elkhound Association of America, Inc., Orthopedic Foundation for Animals, Portuguese Water Dog Foundation, Inc., Rottweiler Health Foundation, Staffordshire Terrier Club of America, Inc., Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation, United States Australian Shepherd Association, United States Australian Shepherd Foundation

Breed(s): -All Dogs

Research Program Area: Musculoskeletal Conditions and Disease

Abstract

Canine hip dysplasia is a common developmental disorder of the hip joint that severely affects a dog's quality of life. As the disease has several genetic risk elements and is influenced by environmental factors like diet and exercise, it is of paramount importance that genetic association studies are conducted using adequately-sized cohorts of genotyped diseased and healthy animals. Dr. Iivanainen will sample a large population of dogs (>300-400 dogs) so that contributing genetic loci can reliably be discovered. This research group expects that with such a strongly powered study all major genetic risk factors can be uncovered with a high statistical significance. Investigators expect that identified loci will be discovered across breeds. The identification of genetic risk elements will allow the development of genetic tests that can be used in breeding programs to control the disease incidence, as well as further studies regarding the possible role of diet and exercise in hip dysplasia development.

Publication(s)

Mikkola, L., Kyöstilä, K., Donner, J., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2021). An across-breed validation study of 46 genetic markers in canine hip dysplasia. BMC Genomics, 22(1), 68. https://doi.org/10.1186/s12864-021-07375-x

Mikkola, L. I., Holopainen, S., Lappalainen, A. K., Pessa-Morikawa, T., Augustine, T. J. P., Arumilli, M., & Hyt, M. K. (2019). Novel protective and risk loci in hip dysplasia in German Shepherds. PLoS Genetics, 15(7), e1008197. https://doi.org/10.1371/journal.pgen.1008197

Mikkola, L., Holopainen, S., Pessa-Morikawa, T., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2019). Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci BMC Genomics, 20(1027), 1–13. doi.org/10.1186/s12864-019-6422-6