01828: Mapping of Genetic Risk Factors for Canine Hip Dysplasia
Grant Status: Closed
Canine hip dysplasia is a common developmental disorder of the hip joint that severely affects a dog's quality of life. As the disease has several genetic risk elements and is influenced by environmental factors like diet and exercise, it is of paramount importance that genetic association studies are conducted using adequately-sized cohorts of genotyped diseased and healthy animals. Dr. Iivanainen will sample a large population of dogs (>300-400 dogs) so that contributing genetic loci can reliably be discovered. This research group expects that with such a strongly powered study all major genetic risk factors can be uncovered with a high statistical significance. Investigators expect that identified loci will be discovered across breeds. The identification of genetic risk elements will allow the development of genetic tests that can be used in breeding programs to control the disease incidence, as well as further studies regarding the possible role of diet and exercise in hip dysplasia development.
Mikkola, L., Kyöstilä, K., Donner, J., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2021). An across-breed validation study of 46 genetic markers in canine hip dysplasia. BMC Genomics, 22(1), 68. https://doi.org/10.1186/s12864-021-07375-x
Mikkola, L. I., Holopainen, S., Lappalainen, A. K., Pessa-Morikawa, T., Augustine, T. J. P., Arumilli, M., & Hyt, M. K. (2019). Novel protective and risk loci in hip dysplasia in German Shepherds. PLoS Genetics, 15(7), e1008197. https://doi.org/10.1371/journal.pgen.1008197
Mikkola, L., Holopainen, S., Pessa-Morikawa, T., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2019). Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci BMC Genomics, 20(1027), 1–13. doi.org/10.1186/s12864-019-6422-6
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.