1806: A Novel Virus-Based Anti-Tumor Treatment for Canine Osteosarcoma

Grant Status: Closed

Grant Amount: $118,848
Bruce F Smith, VMD, PhD; Auburn University
March 1, 2013 - February 28, 2015

Sponsor(s): American Chesapeake Club, Inc., English Setter Association of America, Inc., Flat-Coated Retriever Foundation, Great Dane Club of America, Great Pyrenees Club of America, Irish Setter Club of America Foundation, Irish Wolfhound Club of America, Inc., Leonberger Health Foundation, Newfoundland Club of America Charitable Trust, Old English Sheepdog Club of America, Rottweiler Health Foundation, Samoyed Club of America Education & Research Foundation

Breed(s): Rottweiler, Greyhound, Saint Bernard, Great Dane, Doberman Pinscher, Irish Setter, Golden Retriever
Research Program Area: Oncology - Osteosarcoma
Donate to Support this Research Program Area

Abstract

Osteosarcoma is an aggressive canine bone cancer, accounting for around 6% of all canine cancers. Even with the standard-of-care therapy of amputation and chemotherapy, the prognosis is poor, with most dogs dying due to tumor spread (metastasis) within one year, and less than 20% surviving to 2 years following diagnosis. Therefore, improved strategies to treat metastatic disease are needed. Using a novel approach, Dr. Smith has engineered a virus to multiply in and kill tumor cells while sparing normal cells. Preliminary studies have demonstrated that this virus-based anti-tumor treatment is safe when administered to canine osteosarcoma patients and is potentially efficacious in treating osteosarcoma. While this virus was hypothesized to kill osteosarcoma cells through its replication, Dr. Smith's research team hypothesizes that the viral vector may also stimulate an anti-tumor immune response in addition to the expected anti-viral response. In this study, the efficacy and mechanism of action of the virus-based anti-tumor treatment will be evaluated.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

  

© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.