01684-A: Improved Method for Early Diagnosis of Atypical Cushing's Disease

Grant Status: Closed

Grant Amount: $11,631.6
Linda Frank, DVM; University of Tennessee
November 1, 2011 - April 30, 2013

Sponsor(s): Cardigan Welsh Corgi Health Foundation, Inc., Collie Health Foundation, Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Portuguese Water Dog Foundation

Breed(s): Pembroke Welsh Corgi, Papillon, West Highland White Terrier, Petit Basset Griffon Vendeen, Schipperke, Pharaoh Hound, Scottish Terrier, Australian Terrier, Glen of Imaal Terrier, Miniature Schnauzer, Skye Terrier, Silky Terrier, Gordon Setter, Dandie Dinmont Terrier
Research Program Area: Endocrinology
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Project Summary

Twenty-eight dogs were enrolled in the study to compare cortisol concentrations among healthy dogs, dogs with excess cortisol associated with pituitary dependent Cushing's syndrome and dogs categorized as having "atypical" Cushing's syndrome. The latter is diagnosed when dogs have clinical signs suggestive of excess cortisol (drinking a lot, infections, losing hair) but increases in peak cortisol concentration are not detected with routine tests. Nine hourly blood samples were collected from each dog through a catheter. The serum was saved and then sent to a lab for determination of cortisol concentrations. The cortisol concentrations from dogs within each group will be statistically compared to see if dogs with "atypical" Cushing's syndrome have similar cortisol levels to those with pituitary dependent Cushing's syndrome.


Frank, L. A., Henry, G. A., Whittemore, J. C., Enders, B. D., Mawby, D. I., & Rohrbach, B. W. (2015). Serum Cortisol Concentrations in Dogs with Pituitary-Dependent Hyperadrenocorticism and Atypical Hyperadrenocorticism. Journal of Veterinary Internal Medicine, 29(1), 193–199. https://doi.org/10.1111/jvim.12500

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