01472: Enhanced Killing of Malignant Histiocytosis with a Novel Combination of Anti-Tumor Drugs

Grant Status: Closed

Grant Amount: $57,526
Steven W. Dow, DVM, PhD; Colorado State University
January 1, 2011 - December 31, 2013

Sponsor(s): American Maltese Association, Boston Terrier Club of America, Golden Retriever Foundation, Miniature Pinscher Club of America, Inc., Papillon Club of America, Pug Dog Club of America, Inc., Yorkshire Terrier Club of America

Breed(s): Golden Retriever, Flat-Coated Retriever, Bernese Mountain Dog, Rottweiler
Research Program Area: Oncology
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Project Summary

The studies supported by this CHF grant sought to determine whether the combination of liposomal clodronate, a macrophage depleting agent, and CCNU, a chemotherapy drug, were more effective in treating canine malignant histiosarcoma than either agent alone. The studies found that the combination of both drugs together was not significantly more effective than either alone, though there was a trend towards better long-term survival in dogs treated with both agents. A larger study would be required to more fully address this question. Thus, there remains an unmet need for new treatments to more effectively manage MH in dogs.


Hafeman, S. D., Varland, D., & Dow, S. W. (2012). Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Veterinary and Comparative Oncology, 10(1), 44–56. https://doi.org/10.1111/j.1476-5829.2011.00274.x

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