1424: Genetic Analysis of Cleft Palate/Lip

Grant Status: Closed

Grant Amount: $40,825
Danika L Bannasch, DVM, PhD; University of California, Davis
January 1, 2011 - December 31, 2011

Sponsor(s): Basenji Club of America, Inc. & Basenji Health Endowment, Border Terrier Club of America, English Springer Spaniel Field Trial Association, German Shepherd Dog Club of America, Golden Retriever Foundation, Labrador Retriever Club, Miniature Pinscher Club of America, Inc., Norwegian Elkhound Association of America, Inc., Pembroke Welsh Corgi Club of America, Siberian Husky Club of America, Versatility in Poodles, Inc.

Breed(s): Rhodesian Ridgeback, Brittany, Whippet, Nova Scotia Duck Tolling Retriever, Weimaraner
Research Program Area: Musculoskeletal Conditions and Disease
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Project Summary

The Bannasch Laboratory at the University of California, Davis and the Wade Laboratory at the University of Sydney are working towards identifying the genes responsible for cleft palate and cleft lip in the dog. We have identified four regions that cause autosomal recessive cleft palate within the Nova Scotia Duck Tolling Retriever (NSDTR). We have identified the specific mutation that causes cleft palate in one of these regions which we call CP1. We have recently received funding from the national Institutes of Health to expand this project to include all breeds of dogs.


Wolf, Z. T., Brand, H. A., Shaffer, J. R., Leslie, E. J., Arzi, B., Willet, C. E., … Bannasch, D. L. (2015). Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate. PLOS Genetics, 11(3), e1005059. https://doi.org/10.1371/journal.pgen.1005059

Wolf, Z. T., Leslie, E. J., Arzi, B., Jayashankar, K., Karmi, N., Jia, Z., … Bannasch, D. L. (2014). A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genetics, 10(4), e1004257. https://doi.org/10.1371/journal.pgen.1004257

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