01354-A: Heritability of Calcium Oxalate Urolithiasis in Miniature Schnauzers

Grant Status: Closed

Grant Amount: $12,122.25
Ned E. Patterson, DVM, PhD; University of Minnesota
September 1, 2009 - August 31, 2011

Sponsor(s): Bichon Frise Club of America, Inc., Borzoi Club of America, Briard Club of America Health & Education Trust, Clumber Spaniel Club of America, Flat-Coated Retriever Foundation, Great Pyrenees Club of America, Saluki Health Research, Inc.

Breed(s): Miniature Schnauzer
Research Program Area: Kidney & Urological Disease
Donate to Support this Research Program Area

Project Summary

The study on heritability of calcium oxalate urinary stones in Miniature Schnauzers met with great success. We met our goal with over 100 dogs enrolled in the study; half were affected by calcium oxalate stones while the other half were older stone-free dogs. Through pedigree analysis, we determined that the most likely mode of inheritance is autosomal dominant, though other types of inheritance are still possible. DNA extraction has been completed on all samples to date, and the DNA is being stored at the University of Minnesota Canine and Equine Genetics Laboratory. This DNA will be used in a future genome wide study to determine the genetic basis of calcium oxalate stones in Miniature Schnauzers. One surprising finding of our study was an very high prevalence of bladder stones in older Miniature Schnauzers with no history of stones or urinary symptoms. Of the dogs screened as controls for the study (all over 8 years old), 21% were identified to have stones visible on abdominal X-rays. This prevalence is dramatically higher than the all-breed prevalence of 0.3 - 2% reported in veterinary literature. We plan to report this finding to the veterinary field to improve awareness of the common nature of this problem. The high prevalence also stresses the need for further investigations into the genetic basis of this disease.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

  

© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.