01233-A: Examining Hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers Utilizing Whole Genome SNP Association

Grant Status: Closed

Grant Amount: $12,862
Danika L Bannasch, DVM, PhD; University of California, Davis
June 1, 2009 - May 31, 2010

Sponsor(s): American Cavalier King Charles Spaniel Club Charitable Trust, Briard Club of America Health & Education Trust, Flat-Coated Retriever Foundation, Poodle Club of America Foundation

Breed(s): Nova Scotia Duck Tolling Retriever
Research Program Area: Endocrinology
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Project Summary

Addison's disease in the NSDTR has a complicated presentation. Dogs have been diagnosed as early as 7 weeks of age and as old as 11 years. In some cases, other diseases are seen in conjunction with Addison's disease like megaesophagus, hypothyroidism and eye problems. The sequencing of the canine genome has made available some powerful new tools for the investigation of inherited diseases. One of those sets of tools is SNP arrays that can test thousands of markers at one time. Recently, Illumina inc. developed an expanded canine SNP array that can test 173,000 markers at once. We utilized this array to investigate Addison's disease in the NSDTR by comparing markers between affected and unaffected dogs. A significantly associated chromosomal region was identified using this approach. In the future we will evaluate genes in this region for mutations associated with Addison's disease so that a DNA-based test can be offered to breeders.

Publication(s)

Hughes, A. M., Bannasch, D. L., Kellett, K., & Oberbauer, A. M. (2011). Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. The Veterinary Journal, 187(2), 212–216. https://doi.org/10.1016/j.tvjl.2009.10.012
 
Wilbe, M., Jokinen, P., Truvé, K., Seppala, E. H., Karlsson, E. K., Biagi, T., … Lindblad-Toh, K. (2010). Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nature Genetics, 42(3), 250–254. https://doi.org/10.1038/ng.525

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