01180-A: The Prognostic Value of Various Cerebrospinal Fluid Biomarkers in Dogs with Acute Thoracolumbar Disk Herniation
Grant Status: Closed
Project Summary
The researchers have completed project enrollment and all aspects of data analysis. It appears that CSF levels of 3 biomarkers, CK, lactate, and MBP are significantly higher in dogs with poor long-term outcome. The MBP data are particularly interesting as this biomarker appears to offer information that is independent of initial neurologic dysfunction as graded by MFS. In dogs with MRI identified changes within the spinal cord, CK concentrations are also significantly higher. These data are very promising as they may offer alternative means to predict outcome in addition to traditional physical examination-based parameters. They may also act as a means to stratify patient populations for the purposes of clinical trials.
Publication(s)
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
