01077-A: Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals

Grant Status: Closed

Grant Amount: $12,851.06
Madhu S. Dhar, PhD; University of Tennessee
May 1, 2008 - April 30, 2009

Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Estate of Virginia Lyn Tarquinio, German Shepherd Dog Club of America, White Shepherd Genetics Project

Breed(s): -All Dogs
Research Program Area: Endocrinology
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Project Summary

Using molecular biology techniques, this pilot research study confirmed that a novel P-type ATPase, Atp10c is highly expressed in the visceral fat tissue in dogs. This project established reagents and cell culture techniques by which this gene can be studied further in dogs. Preliminary data suggests that this gene and its protein may have important roles in affecting body fat and insulin resistance in companion animals.


Roshwalb, S., Gorman, S., Hurst, S., Bartges, J., Agarwal, S., Sommardahl, C., … Dhar, M. S. (2011). mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score. The Veterinary Journal, 190(1), 173–175. https://doi.org/10.1016/j.tvjl.2010.09.008

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