01062-A: Knee Kinematics, Kinetics and Neuromuscular Patterns in Labrador Retrievers Predisposed to Cranial Cruciate Disease

Grant Status: Closed

Grant Amount: $12,960
Dominique J. Griffon, DVM, PhD; University of Illinois
August 1, 2008 - January 31, 2010


Breed(s): Labrador Retriever
Research Program Area: Musculoskeletal Conditions and Disease
Donate to Support this Research Program Area

Project Summary

Dual energy X-ray absorptiometry (DEXA), radiographs of the rear limbs under sedation and gait analysis of adult Labrador Retrievers was performed to document mechanical characteristics of the canine gait that may explain predisposition to cranial cruciate ligament (CCL) disease. Repartition between non-predisposed or predisposed to CCL disease group is based on the femoral anterversion angle and the tibial plateau slope measured on radiographs. Twenty-three Labrador Retrievers, between 12 and 130 month-old were recruited. Unfortunately, canine hip dysplasia was diagnosed on hip radiographs in two dogs which were excluded from the study and one dog was not able to completely perform the gait analysis section. Therefore, the gait analysis data were collected in twenty trotting dogs over ground and over a treadmill. The large quantity of data is still being analyzed to compare the mechanical characteristics of the canine gait between dogs pre-disposed to CCL and controls.


Griffon, D. J. (2010). A Review of the Pathogenesis of Canine Cranial Cruciate Ligament Disease as a Basis for Future Preventive Strategies. Veterinary Surgery, 39(4), 399–409. https://doi.org/10.1111/j.1532-950X.2010.00654.x
Mostafa, A. A., Griffon, D. J., Thomas, M. W., & Constable, P. D. (2010). Morphometric Characteristics of the Pelvic Limb Musculature of Labrador Retrievers with and without Cranial Cruciate Ligament Deficiency. Veterinary Surgery, 39(3), 380–389. https://doi.org/10.1111/j.1532-950X.2010.00657.x
Ragetly, C. A., Griffon, D. J., Mostafa, A. A., Thomas, J. E., & Hsiao-Wecksler, E. T. (2010). Inverse Dynamics Analysis of the Pelvic Limbs in Labrador Retrievers With and Without Cranial Cruciate Ligament Disease. Veterinary Surgery, 39(4), 513–522. https://doi.org/10.1111/j.1532-950X.2010.00680.x
Unis, M. D., Johnson, A. L., Griffon, D. J., Schaeffer, D. J., Ragetly, G. R., Hoffer, M. J., & Ragetly, C. A. (2010). Evaluation of Intra- and Interobserver Variability and Repeatability of Tibial Plateau Angle Measurements with Digital Radiography Using a Novel Digital Radiographic Program. Veterinary Surgery, 39(2), 187–194. https://doi.org/10.1111/j.1532-950X.2009.00641.x

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software