00871-A: Canine Anal Furunculosis
Grant Status: Closed
Grant Amount: $12,960
Lorna J. Kennedy, PhD; University of Manchester
December 1, 2006 - December 30, 2008
Sponsor(s): German Shepherd Dog Club of America
Breed(s): German Shepherd Dog
Research Program Area: Gastrointestinal Disease
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Project Summary
We have previously identified a gene associated with Anal Furunculosis (AF) in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 24 German Shepherd dogs having AF with 36 unaffected control dogs, which has revealed 46 SNPs that are significantly associated with AF, and are spread over 18 different canine chromosomes. Four of these SNP associations are highly significant and give us great hope that we will be able to identify other genes/loci associated with this disease. If we can identify such genes, it may be possible to start selective breeding to reduce the risk of German Shepherd dogs developing AF.Publication(s)
Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x
Massey, J., Short, A. D., Catchpole, B., House, A., Day, M. J., Lohi, H., … Kennedy, L. J. (2014). Genetics of canine anal furunculosis in the German Shepherd Dog. Immunogenetics, 66(5), 311–324. https://doi.org/10.1007/s00251-014-0766-5
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