00572-A: Heritability of Atopic Dermatitis in West Highland White Terriers

Grant Status: Closed

Grant Amount: $12,916
Thierry Olivry, DVM, PhD; North Carolina State University
April 1, 2005 - March 31, 2006


Breed(s): West Highland White Terrier
Research Program Area: Dermatology and Allergic Disease
Donate to Support this Research Program Area


In dogs, atopic dermatitis (AD) is a very common chronic allergic skin disease that results in severe itching and skin lesions following self-trauma, impairing the quality of life of affected dogs. Atopic dermatitis has a high frequency of occurrence in several dog breeds, and it is especially common in West Highland White Terriers. We intend to collect clinical data, pedigree information and blood samples from Westies affected with AD and from their normal family members to determine the mode of transmission of this disease. Genomic DNA will be extracted from blood samples and stored. In the future, we intend to link the AD trait to a specific chromosomal region of the canine genome. Examination of corresponding regions in human and mouse genomes will result in identification of likely candidate genes. Later studies will evaluate the linkage of AD with candidate genes, with the purpose of identifying the mutation underlying AD in this breed. Results of these studies should permit the identification of puppies carrying the disease before lesions occur, thus allowing elimination of this trait in Westies.


Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
Wong, A. K., Ruhe, A. L., Dumont, B. L., Robertson, K. R., Guerrero, G., Shull, S. M., … Neff, M. W. (2010). A Comprehensive Linkage Map of the Dog Genome. Genetics, 184(2), 595–605. https://doi.org/10.1534/genetics.109.106831

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813


© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.