00567-A: Mapping the Genetic Lesion of Primary Lens Luxation in Lancashire Heelers, Miniature Bull Terriers and Other Terrier Breeds

Grant Status: Closed

Grant Amount: $9,586
David Sargan, MA, PhD; University of Cambridge
January 1, 2005 - December 31, 2005


Breed(s): Miniature Bull Terrier
Research Program Area: Ophthalmology
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Primary Lens Luxations (PLLs) are painful and blinding ocular conditions recessively inherited in a range of terrier and other dog breeds. In this project, we will 1) use linkage disequilibrium mapping to establish the genetic location of the mutation causing PLL in Miniature Bull Terriers and Lancashire Heelers; 2) begin cloning candidate genes for causation of PLL from this region; 3) screen these genes for mutations in PLL dogs of various terrier breeds. Ultimately, our aim is to produce one or more DNA-based tests for PLL in terrier breeds.


Farias, F. H. G., Johnson, G. S., Taylor, J. F., Giuliano, E., Katz, M. L., Sanders, D. N., … Mellersh, C. (2010). An ADAMTS17 Splice Donor Site Mutation in Dogs with Primary Lens Luxation. Investigative Ophthalmology & Visual Science, 51(9), 4716–4721. https://doi.org/10.1167/iovs.09-5142
Sargan, D. R., Withers, D., Pettitt, L., Squire, M., Gould, D. J., & Mellersh, C. S. (2007). Mapping the Mutation Causing Lens Luxation in Several Terrier Breeds. Journal of Heredity, 98(5), 534–538. https://doi.org/10.1093/jhered/esm029

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