454: Analysis of a Candidate Gene for Pancreatic Acinar Atrophy in the German Shepherd Dog

Grant Status: Closed

Grant Amount: $22,680
Keith E. Murphy, PhD; Texas A&M University
October 1, 2004 - September 30, 2005

Sponsor(s): Australian Cattle Dog Club of America

Breed(s): German Shepherd Dog
Research Program Area: Gastrointestinal Disease
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Although pancreatic acinar atrophy is primarily a disease found in the German Shepherd Dog, it is also diagnosed in other breeds such as the Rough Collie and Dachshund. Diagnosis is usually not made until later in life, therefore, affected and carrier dogs are unknowingly bred. When diagnosed, the current 3treatment is enzyme therapy, which has proven effective in managing the disease. However, this treatment can be costly and many owners cannot afford this form of therapy and may be faced with the decision to euthanize their pet. If a causative mutation is found, a genetic test will be developed to determine the affection status of dogs at a very early age, and breeding practices can be altered so that the disease is not passed on to further generations.


Clark, L. A., Wahl, J. M., Steiner, J. M., Zhou, W., Ji, W., Famula, T. R., … Murphy, K. E. (2005). Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog. Mammalian Genome, 16(12), 955–962. https://doi.org/10.1007/s00335-005-0076-1

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