440: A Molecular Evaluation of Two Forms of Canine Cardiomyopathy
Grant Status: Closed
Abstract
Cardiomyopathy is the second most common heart disease diagnosed in the dog. The two most common forms of canine cardiomyopathy are dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC). Both are adult onset, familial diseases that frequently progress to sudden death and/or heart failure. We hypothesize that these diseases can each be mapped to a separate, location on a canine chromosome. The objective of this study is to perform a genome wide scan using DNA samples from families of Doberman Pinschers with DCM and Boxers with ARVC. Canine genetic markers will be evaluated to identify a chromosomal location linked to each of these diseases. The identification of a chromosomal location linked to the disease will allow additional evaluation of this region for a gene responsible for the disease and may be useful for the identification of at risk dogs even before the causative gene is identified.
Publication(s)
Related Grants
- 00228T: A Comparative Evaluation of the Concealed and Overt Forms of Arrhythmogenic Right Ventricular Cardiomyopathy: Risk Factors Associated with the Development of Symptoms in Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy
- 02808-MOU: Identification of a Second Genetic Risk Allele(s) Associated with the Development of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
