00395-A: Elevated Serum Alkaline Phosphatase Activity in Scottish Terriers: Benign Hyperphosphatasemia or an Indicator of Disease?

Grant Status: Closed

Grant Amount: $12,733
Kurt Zimmerman, DVM, PhD; Virginia-Maryland Regional College of Veterinary Medicine
July 1, 2005 - June 30, 2007


Breed(s): Scottish Terrier
Research Program Area: Hepatic Disease
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The purpose of this study is to identify distinguishing clinical and laboratory parameters in adult Scottish Terriers with unexplained elevations of serum alkaline phosphatase (ALKP). Ten affected adult dogs (>12 months of age) will be evaluated along with ten dogs of the same breed and age range that have serum ALKP activity within an established reference interval. All dogs will undergo routine complete blood count, serum biochemistries and other tests. Activity of ALKP isoenzymes will be measured in all dogs using the wheat germ lectin/levamisole inhibition assay. In addition, an ultrasound-guided liver biopsy for cytologic and histologic examination will be collected on the ten affected dogs. The investigators anticipate finding a specific pattern of laboratory results, in particular isoenzyme elevation, that will allow differentiation of dogs with benign hyperphosphatasemia from those with other causes of elevated ALKP.


Zimmerman, K. L., Panciera, D. L., Panciera, R. J., Oliver, J. W., Hoffmann, W. E., Binder, E. M., … Kinnarney, J. H. (2010). Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers. Journal of the American Veterinary Medical Association, 237(2), 178–186. https://doi.org/10.2460/javma.237.2.178

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