00373A: Mapping Genes Associated with Osteosarcoma in Large Dog Breeds
Grant Status: Closed
Abstract
Eight thousand to ten thousand cases of osteosarcoma, a malignant bone tumor, are reported in dogs in the United States annually, representing a significant health concern. In the majority of cases, spread of the tumor throughout the body and death follows within a few years. Osteosarcoma affects all dogs, but the disease frequency is considerably higher in large and giant breeds, including the long-limbed hounds (Irish Wolfhound, Great Dane, Greyhound, Scottish Deerhound, Rhodesian Ridgeback, Great Pyrenees and Borzoi) and Mastiff-type breeds (Rottweiler, Labrador Retriever, Flat-Coated Retriever, Golden Retriever, Mastiff, Bullmastiff, Saint Bernard, Irish Setter, and Newfoundland). It is clear the genetics play an important role. We propose to identify the genetic risk factors for osteosarcoma in two breeds: Greyhound and Rottweiler. While certain characteristics of these two breeds make them ideal to study, we expect that the genes identified in these breeds may also be associated with osteosarcoma in related breeds. This study should lead to the development of genetic tests for osteosarcoma that could be used to eliminate carriers from breeding populations, eventually reducing the frequency of this devastating cancer. Ultimately, it could also lead to improvements in treatment of osteosarcoma.
Publication(s)
Karlsson, E. K., Baranowska, I., Wade, C. M., Salmon Hillbertz, N. H. C., Zody, M. C., Anderson, N., … Lindblad-Toh, K. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nature Genetics, 39(11), 1321–1328. https://doi.org/10.1038/ng.2007.10
Karlsson, E. K., & Lindblad-Toh, K. (2008). Leader of the pack: Gene mapping in dogs and other model organisms. Nature Reviews Genetics, 9(9), 713–725.https://doi.org/10.1038/nrg2382
Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Lindblad-Toh, K. (2013). Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biology, 14(12), R132. https://doi.org/10.1186/gb-2013-14-12-r132
Salmon Hillbertz, N. H. C., Isaksson, M., Karlsson, E. K., Hellmén, E., Pielberg, G. R., Savolainen, P., … Andersson, G. (2007). Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback Dogs. Nature Genetics, 39(11), 1318–1320.https://doi.org/10.1038/ng.2007.4
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