00352: Genetic Basis of Exercise-Induced Collapse in Labrador Retrievers

Grant Status: Closed

Grant Amount: $64,722
James R. Mickelson, PhD; University of Minnesota
January 1, 2005 - June 30, 2007


Breed(s): Labrador Retriever
Research Program Area: Neurology
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The Exercise Induced Collapse (EIC) syndrome causes some very athletic Labrador Retrievers to develop life-threatening collapse during retrieving exercise. Dogs affected with EIC cannot continue with strenuous retriever training although they can live good lives as family pets. Our previous work, which has collected pedigree, clinical and laboratory data from affected, as well as control dogs, has determined that there is clearly a heritable basis for the condition. However, this work could not yet define the precise physiological basis for collapse, nor candidate genes that could be responsible for the condition. In this project we will employ a molecular genetic strategy to locate the chromosomal position of the EIC gene in dogs from affected pedigrees. These approaches will ultimately allow the identification of the EIC gene itself and the development of a DNA testing program to control its propagation.


Patterson, E. E., Minor, K. M., Tchernatynskaia, A. V., Taylor, S. M., Shelton, G. D., Ekenstedt, K. J., & Mickelson, J. R. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics, 40(10), 1235–1239. https://doi.org/10.1038/ng.224

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