02336: Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels
Grant Status: Closed
Glaucoma is a leading cause of irreversible blindness and globe removal (enucleation) in dogs. Primary angle closure glaucoma (PACG) is the most common form of glaucoma in dogs whereby acute blockage of the iridocorneal angle leads to a rapid increase in intraocular pressure. Consequently, PACG is painful, demands immediate medical attention, and often causes incurable vision loss. The American Cocker Spaniel (ACS) has the highest reported prevalence of any canine breed for PACG. The investigators will study the genetics of PACG in the ACS to identify potential disease-causing loci and variants. Dogs will be extensively phenotyped as PACG cases or controls using advanced imaging equipment used to investigate glaucoma in human patients. Identification of genetic markers associated with PACG in ACSs will facilitate the development of a genetic test to inform breeding programs. Furthermore, identification of the molecular basis of PACG may help elucidate novel therapeutic or testing strategies in the management of this blinding disease that may be translatable to the human condition.
Fawver, B. Researchers study genetic causes of glaucoma in Cocker Spaniels. Purina Pro Club. Published online Oct 2017. https://purinaproclub.com/resource-library/pro-club-updates/researchers-study-genetic-causes-of-glaucoma-in-cocker-spaniels/
Fawver, B. Dog Update: Primary angle-closure glaucoma is focus of genetic studies in dogs.https://www.purinaproclub.com/resources/dog-articles/breed-updates/dog-update-spring-2019
Park, S, MI Casanova, DL Bannasch, NL Daley, S Kim...S Thomasy. Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility. (2022, May 18). https://doi.org/10.21203/rs.3.rs-1634088/v1
Gomes, F. E., Casanova, M. I., Mouttham, L., Bannasch, D. L., Park, S., Kim, S., Young, L. J., Daley, N. L., Thomasy, S. M., Castelhano, M. G., Ledbetter, E. C., Holmberg, B., Boyd, R., Woerdt, A. V. D., McDonald, J., & Hayward, J. J. (2022). A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. American Journal of Veterinary Research, 1(aop), 1–8. https://doi.org/10.2460/ajvr.22.07.0106
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