2462: Molecular Genetic Study of Fanconi Syndrome in Basenjis

Grant Status: Closed

Grant Amount: $18,000
Gary S. Johnson, DVM, PhD; University of Missouri, Columbia
January 1, 2003 - December 31, 2003

Sponsor(s): Basenji Club of America, Inc. & Basenji Health Endowment

Breed(s): Basenji
Research Program Area: Kidney & Urological Disease
Donate to Support this Research Program Area


The Basenji Club of America considers Fanconi Syndrome the problem of highest priority in the 2001 Parent Club Survey. Our long-term goals are to identify the mutation responsible for Fanconi Syndrome in Basenjis and to use this information to design a DNA-based test for carriers of this disease. This test would enable Basenji breeders to avoid producing future generations of Basenjis with Fanconi Syndrome. Our specific objectives are (1) to isolate DNA from Basenjis with Fanconi Syndrome and their close relatives; (2) to evaluate variant sequences in mitochondrial DNA from an affected Basenji as possible causes of Fanconi Syndrome; (3) to evaluate a region of canine chromosome 30 that corresponds to a chromosomal region responsible for human Fanconi Syndrome locus and, if necessary, to extend the evaluation to cover the entire chromosome; and (4) to establish an internet website for recruiting DNA samples and disseminating information about Fanconi Syndrome and its management. The proposed experiments should localize the Basenji Syndrome locus if it is in the mitochondrial genome or on canine chromosome 30. If the Fanconi locus is elsewhere in the nuclear genome, the proposed experiments should test the feasibility of finding it by whole-genome mapping in future studies.


None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813


© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.