1873: Sequential Clinical Evaluation, Mode of Inheritance, and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers
Grant Status: Closed
Grant Amount: $67,930
Shelly Vaden, DVM, PhD; North Carolina State University
October 5, 1999 - October 4, 2001
Sponsor(s): Soft Coated Wheaten Terrier Club of America, Inc.
Breed(s): Soft Coated Wheaten Terrier
Research Program Area: Gastrointestinal Disease
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Abstract
Soft Coated Wheaten Terriers (SCWT) are at risk for protein wasting diseases of the kidneys and intestines. Clinical Signs of this disease vary but can be quite severe, including death. We have demonstrated that the disease is associated with food allergies. We propose to continue the evaluation of a colony of SCWT and SCWT-cross dogs that are at risk for the development of this disorder. In face, some of these dogs already have the disease. Sequential evaluation of these dogs will allow us to characterize the early clinical signs, progressive nature, and mode of inheritance of this disease. These findings will allow for future development of a genetic marker as well as selective breeding programs aimed at elimination of this disorder from the SCWT population. Once dogs become overtly affected with this disease, we will enter them into a treatment trial, using methods known to be effective in food allergies. Information obtained from this trial will be invaluable in developing treatment regimens for affected SCWT in the population at large. Results of this study also have applicability to other breeds of dogs that are at risk for food allergies or specific forms of gastrointestinal and renal disease.Publication(s)
Vaden, S. L., Hammerberg, B., Davenport, D. J., Orton, S. M., Trogdon, M. M., Melgarejo, L. T., … Williams, D. A. (2000). Food Hypersensitivity Reactions in Soft Coated Wheaten Terriers with Protein-Losing Enteropathy or Protein-Losing Nephropathy or Both: Gastroscopic Food Sensitivity Testing, Dietary Provocation, and Fecal Immunoglobulin E. Journal of Veterinary Internal Medicine, 14, 60–67.
Vaden, S. L., Littman, M. P., & Cianciolo, R. E. (2013). Familial renal disease in Soft-Coated Wheaten Terriers. Journal of Veterinary Emergency and Critical Care, 23(2), 174–183. https://doi.org/10.1111/vec.12027
Vaden, S. L., Sellon, R. K., Melgarejo, L. T., Williams, D. A., Trogdon, M. M., VanCamp, S. D., & Argenzio, R. A. (2000). Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. American Journal of Veterinary Research, 61(5), 518–524. https://doi.org/10.2460/ajvr.2000.61.518
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