Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 1425 Research Program Area: Epilepsy Initiative |
Identification of Epilepsy-Causing Mutations from the Associated Loci by Next-Generation Resequencing Koskinen, L. L. E., Seppälä, E. H., Belanger, J. M., Arumilli, M., Hakosalo, O., Jokinen, P., … Lohi, H. (2015). Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene. BMC Genomics, 16(1). https://doi.org/10.1186/s12864-015-1651-9 Koskinen, L. L. E., Seppälä, E. H., Weissl, J., Jokinen, T. S., Viitmaa, R., Hänninen, R. L., … Lohi, H. (2017). ADAM23 is a common risk gene for canine idiopathic epilepsy. BMC Genetics, 18(1). https://doi.org/10.1186/s12863-017-0478-6 Lequarré, A.-S., Andersson, L., André, C., Fredholm, M., Hitte, C., Leeb, T., … Georges, M. (2011). LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. The Veterinary Journal, 189(2), 155–159. https://doi.org/10.1016/j.tvjl.2011.06.013 |
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Grant Number: 01900-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Prevalence of Vector Borne Disease in Dogs with Clinical Signs of Immune Mediated Disease Kidd, L., Qurollo, B., Lappin, M., Richter, K., Hart, J. R., Hill, S., … Breitschwerdt, E. B. (2017). Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease. Journal of Veterinary Internal Medicine, 31(4), 1081–1090. https://doi.org/10.1111/jvim.14735 |
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Grant Number: 00652-A Research Program Area: Immunology and Infectious Disease |
A New Bartonella Infection in Domestic Dogs from Northern California Harms, A., Segers, F. H. I. D., Quebatte, M., Mistl, C., Manfredi, P., Körner, J., … Dehio, C. (2017). Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella. Genome Biology and Evolution, 9(3), 761–776. https://doi.org/10.1093/gbe/evx042
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Koehler, J. E., MacDonald, K. A., … Chomel, B. B. (2009). Infective Endocarditis in a Dog and the Phylogenetic Relationship of the Associated “Bartonella rochalimae” Strain with Isolates from Dogs, Gray Foxes, and a Human. Journal of Clinical Microbiology, 47(3), 787–790. https://doi.org/10.1128/JCM.01351-08
Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., & Chomel, B. B. (2007). Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California. Journal of Clinical Microbiology, 45(8), 2411–2418. https://doi.org/10.1128/JCM.02539-06
Henn, Jennifer B., Chomel, B. B., Boulouis, H.-J., Kasten, R. W., Murray, W. J., Bar-Gal, G. K., … Baneth, G. (2009). Bartonella rochalimae in Raccoons, Coyotes, and Red Foxes. Emerging Infectious Diseases, 15(12), 1984–1987. https://doi.org/10.3201/eid1512.081692 |
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Grant Number: 02238-A Research Program Area: Blood Disorders |
Effect of Platelet Count on Platelet Function Tests in Dogs Nash, K. J., Bacek, L. M., Christopherson, P. W., & Spangler, E. A. (2017). In vitro effect of blood cell counts on multiple-electrode impedance aggregometry in dogs. American Journal of Veterinary Research, 78(12), 1380–1386. https://doi.org/10.2460/ajvr.78.12.1380 |
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Grant Number: 01894-A Research Program Area: Immunology and Infectious Disease, Tick-Borne Disease Initiative |
Documentation of Disease-Causing Ticks in a Field Trial Environment for the Purpose of Developing Practical and Cost-Effective Strategies for Tick Control Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016a). Comparison of novel and conventional methods of trapping ixodid ticks in the southeastern U.S.A. Medical and Veterinary Entomology, 30(2), 123–134. https://doi.org/10.1111/mve.12160
Mays, S. E., Houston, A. E., & Trout Fryxell, R. T. (2016b). Specifying Pathogen Associations of Amblyomma maculatum (Acari: Ixodidae) in Western Tennessee. Journal of Medical Entomology, 53(2), 435–440. https://doi.org/10.1093/jme/tjv238
Mays, Sarah E, Hendricks, B. M., Paulsen, D. J., Houston, A. E., & Fryxell, R. T. T. (2014). Prevalence of five tick-borne bacterial genera in adult Ixodes scapularis removed from white-tailed deer in western Tennessee. Parasites and Vectors, 7, 473.
Trout Fryxell, R. T., Moore, J. E., Collins, M. D., Kwon, Y., Jean-Philippe, S. R., Schaeffer, S. M., … Houston, A. E. (2015). Habitat and Vegetation Variables Are Not Enough When Predicting Tick Populations in the Southeastern United States. PLOS ONE, 10(12), e0144092. https://doi.org/10.1371/journal.pone.0144092
Trout Fryxell, Rebecca T., Hendricks, B. M., Pompo, K., Mays, S. E., Paulsen, D. J., Operario, D. J., & Houston, A. E. (2017). Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma , Ehrlichia , and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. Vector-Borne and Zoonotic Diseases, 17(8), 527–538. https://doi.org/10.1089/vbz.2016.2091 |
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Grant Number: 01188-A Research Program Area: Lung and Respiratory Disease |
Capacity for Respiratory-Based Thermoregulation in Brachycephalic Breeds Davis, M. S., Cummings, S. L., & Payton, M. E. (2017). Effect of brachycephaly and body condition score on respiratory thermoregulation of healthy dogs. Journal of the American Veterinary Medical Association, 251(10), 1160–1165. https://doi.org/10.2460/javma.251.10.1160 |
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Grant Number: 01866-A Research Program Area: Cardiology |
Enhancing Treatment of Mitral Valve Disease through the Identification of Biological Markers of Disease Winter, R. L., Saunders, A. B., Gordon, S. G., Miller, M. W., Fosgate, G. T., Suchodolski, J. S., & Steiner, J. M. (2017). Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays. Veterinary Clinical Pathology, 46(2), 299–307. http://doi.org/10.1111/vcp.12495 Winter, R. L., Saunders, A. B., Gordon, S. G., Buch, J. S., & Miller, M. W. (2017). Winter, R. L., Saunders, A. B., Gordon, S. G., Buch, J. S., & Miller, M. W. (2017). Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease. Journal of Veterinary Cardiology, 19(2), 124–131. http://doi.org/https://doi.org/10.1016/j.jvc.2016.11.001 |
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Grant Number: 01822 Research Program Area: Oncology |
Beyond the Genome: The Intersection of Genes and the Environment in Canine Cancer Janowitz Koch, I., Clark, M. M., Thompson, M. J., Deere-Machemer, K. A., Wang, J., Duarte, L., … vonHoldt, B. M. (2016). The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves. Molecular Ecology, 25(8), 1838–1855. https://doi.org/10.1111/mec.13480 Mariano, R., & vonHoldt, B. (2016). The canine X chromosome is a sink for canine endogenous retrovirus transposition. Gene Reports, 4, 169–176. https://doi.org/10.1016/j.genrep.2016.05.003 Thompson, M. J., vonHoldt, B., Horvath, S., & Pellegrini, M. (2017). An epigenetic aging clock for dogs and wolves. Aging, 9(3), 1055–1068. https://doi.org/10.18632/aging.101211 |
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Grant Number: 01892-A Research Program Area: Musculoskeletal Conditions and Disease |
Development of Novel Knee Braces As an Alternative to Surgical Intervention in Cranial Cruciate Ligament Disease Bertocci, G. E., Brown, N. P., & Mich, P. M. (2017). Biomechanics of an orthosis-managed cranial cruciate ligament-deficient canine stifle joint predicted by use of a computer model. American Journal of Veterinary Research, 78(1), 27–35. https://doi.org/10.2460/ajvr.78.1.27 |
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Grant Number: 02261-MOU Research Program Area: Dermatology and Allergic Disease |
Improvement of Risk Assessments for Dermatomyositis Testing Evans, J. M., Noorai, R. E., Tsai, K. L., Starr-Moss, A. N., Hill, C. M., Anderson, K. J., … Clark, L. A. (2017). Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLOS Genetics, 13(2), e1006604. https://doi.org/10.1371/journal.pgen.1006604 |
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Grant Number: 01759 Research Program Area: Oncology - Hemangiosarcoma |
Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma Dickerson, E., & Bryan, B. (2015). Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma. Veterinary Sciences, 2(3), 270–292. https://doi.org/10.3390/vetsci2030270
Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025
Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165
Im, K. S., Kim, J. H., Graef, A. J., Cornax, I., Seelig, D. M., O’Sullivan, M. G., … Modiano, J. F. (2017). Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type. Journal of Comparative Pathology, 156(1), 37–41. https://doi.org/10.1016/j.jcpa.2016.11.271
Kim, J.-H., Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
Kim, J.-H., Graef, A., Dickerson, E., & Modiano, J. (2015). Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives. Veterinary Sciences, 2(4), 388–405. https://doi.org/10.3390/vetsci2040388
Rodriguez, A. M., Graef, A. J., LeVine, D. N., Cohen, I. R., Modiano, J. F., & Kim, J.-H. (2015). Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma. Journal of Veterinary Internal Medicine, 29(4), 1088–1097. https://doi.org/10.1111/jvim.13570
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Grant Number: 2401 Research Program Area: Lung and Respiratory Disease |
Characterization of the Clinical Features of Idiopathic Pulmonary Fibrosis in the West Highland White Terrier Corcoran, B. M., King, L. G., Schwarz, T., Hammond, G., & Sullivan, M. (2011). Further characterisation of the clinical features of chronic pulmonary disease in West Highland White Terriers. Veterinary Record, 168(13), 355–355. https://doi.org/10.1136/vr.c6519
Thierry, F., Handel, I., Hammond, G., King, L. G., Corcoran, B. M., & Schwarz, T. (2017). Further characterization of computed tomographic and clinical features for staging and prognosis of idiopathic pulmonary fibrosis in West Highland White Terriers. Veterinary Radiology & Ultrasound, 58(4), 381–388. https://doi.org/10.1111/vru.12491 |
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Grant Number: 02257 Research Program Area: Neurology, Epilepsy Initiative |
Identification of Genetic Risk Factors for Canine Epilepsy
Villani, N. A., Bullock, G., Michaels, J. R., Yamato, O., O’Brien, D. P., Mhlanga Mutangadura, T., … Katz, M. L. (2019). A mixed breed dog with neuronal ceroid lipofuscinosis is homozygous for a CLN5 nonsense mutation previously identified in border collies and Australian cattle dogs. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2019.04.003 |
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Grant Number: 01843 Research Program Area: Oncology |
Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease Culver, S., Ito, D., Borst, L., Bell, J. S., Modiano, J. F., & Breen, M. (2013). Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy. Veterinary Clinical Pathology, 42(3), 314–322. https://doi.org/10.1111/vcp.12055 Roode, S. C., Rotroff, D., Avery, A. C., Suter, S. E., Bienzle, D., Schiffman, J. D., … Breen, M. (2015). Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation. Chromosome Research, 23(4), 681–708. https://doi.org/10.1007/s10577-015-9475-7 Roode, S. C., Rotroff, D., Richards, K. L., Moore, P., Motsinger-Reif, A., Okamura, Y., … Breen, M. (2016). Comprehensive genomic characterization of five canine lymphoid tumor cell lines. BMC Veterinary Research, 12(1). https://doi.org/10.1186/s12917-016-0836-z |
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Grant Number: 01856-A Research Program Area: Musculoskeletal Conditions and Disease |
Identifying the Best Source of Stem Cells for Treatment of Cranial Cruciate Ligament Disease Duan, W., & Lopez, M. J. (2016). Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Stem Cell Reviews and Reports, 12(2), 257–268. https://doi.org/10.1007/s12015-015-9634-4 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
